Coenzyme Q10

Information About Coenzyme Q10 Dietary Supplements

What is Coenzyme Q10 (Co Q10)?

Discovered in 1957, Co Q10 – also known as Ubiquinone – is a vitamin-like nutrient which is necessary for energy production in the body.

It is often called the “spark plug” that ignites the biochemical engines of mitochondria, the tiny energy factories in cells where oxygen and fat are burned.

Usually Co Q10 is found in abundant quantities throughout the body. However, studies have found that levels of Coenzyme Q10 are low in people with heart disease, and most Co Q10 research is focused on heart disease.

Now, weight loss researchers believe that Co Q10 may have a role in reducing obesity.

More About CoEnzyme Q10

The coenzyme Q10 is a substance without, which the body cells could not produce energy. Its antioxidant effect is indirect in contrast to the direct antioxidants like vitamins E and C and beta-carotene, which bind already formed free radicals. Actually, both types of antioxidants are complemented to defense the cell.

The Q10, however does not supply only with food, its can be synthesized by the organism. It is proved that after 20-th years, its quantity in cells gradually decreases, and its outgo at stress and huge load up growths, too.

From the other side, Q10 synthesizes in the body from the tyrosine amino acid. The synthesis process has 17 stages, which are regulated by several enzyme systems and requires participation of seven vitamins: B2, B3, B5 (pantotenic acid), B6, B9 (folic acid), B12,  and other microelements!!! The ability of the body to fulfill the Q10 deficiency by the food is little, because its content in the regular foods, like meat, liver etc. is poor.

These products are categorically contra-indicated for people with high blood cholesterol, ill from atherosclerosis and other metabolic diseases. Then the alternative is additional intake

How Co Q10 Supplements May Help Weight Loss

Some people with a family history of obesity may have a slower rate of “thermogenesis” – the production of heat energy by the body as it digests and absorbs food.

This low rate contributes to a slower metabolism, since during thermogenesis metabolic rate increases. A sluggish thermogenic response suggests that people who are obese may have a genetic flaw in energy production, possibly due to a deficiency in Co Q10.

Co Q10 Supplements Weight Loss Study

In one study, levels of Co Q10 were found to be low in 50 percent of the subjects, all of whom were obese. So researchers gave nine of the subjects 100 mg of Co Q10 daily, and instructed them to follow a very low-calorie diet.

(Five of the nine were deficient in Co Q10.) After 8-9 weeks, the average weight loss in the Co Q10-deficient group was nearly 30 lb, compared to 13 lb in those who had normal levels of Co Q10.

This finding hints that people who have normal levels of Co Q10 may already have efficient metabolisms; therefore, their weight loss was not as dramatic as the weight loss in those who may have had their slow metabolisms “boosted” by Co Q10.

Considering that 52 percent of obese people may have slow metabolisms, the odds are good that Co Q10 supplements may help people lose weight. More research is needed, however.

Why do we have low levels of CoQ10 in the blood?

Out body’s CoQ10 levels decrease as we grow older. However, significantly lower levels of CoQ10 in the blood have been associated with patients who are experiencing cardiac problems or have just gone through a heart failure. They are also low in patients suffering from cancer, diabetes, muscular dystrophies, and hypertension.

What foods are rich in CoQ10?

The foods that are known to be rich in coenzyme Q10 are mainly poultry, meat, fish, nuts, soybeans, and canola. Fruits, vegetables, egg, and other dairy products give a moderate amount of coenzyme Q10. However, cooking fruits, vegetables, and eggs make them lose a significant level of the coenzyme Q10 they contain.

What diseases can CoQ10 help?

Several clinical trials were made to determine the effects of CoQ10 to patients with these given medical conditions. Most of the clinical trials yielded positive results where CoQ10 is said to have helped in some way along with the right medications.

  • Coenzyme Q10 deficiency.
  • Mitochondrial disorders.
  • Cardiac problems.
  • High blood pressure.
  • High triglycerides and cholesterol levels.
  • Liver failure.
  • Kidney failure.
  • Obesity
  • Migraine.
  • Alzheimer’s disease.
  • Parkinson’s disease.
  • Cancer.
  • Chronic fatigue syndrome.
  • Age-related macular degeneration.
  • Asthma.

Co Q10 Supplements – Health Benefits

Co Q10 plays an important role in preventing atherosclerosis by limiting the amount of fat deposited in the arterial wall.

In addition, several studies have documented a significant reduction of angina symptoms with Co Q10 supplements. One pioneering study published in the American Journal of Cardiology found that people who took Co Q10 experienced a 50 percent reduction in anginal events and demonstrated improved exercise tolerance.

Co Q10 can also help those with high blood pressure. One clinical trial demonstrated an approximately 20-point drop in systolic blood pressure and a 10-point drop in diastolic blood pressure after 10 weeks of Co Q10 therapy.

What is the usual recommended dosage of CoQ10 supplements?

The usual dosage ranges from 30-300 mg per day but the suggested dosage by most medical practitioners is 100 mg. This dosage may still vary as each patient has a different medical condition. Prolonged use of CoQ10 supplement has also been studied not to cause any liver toxicity at all.

Co Q10 is relatively safe and well tolerated. As it is fat-soluble, Co Q10 should be taken with food. But before taking Co Q10, check with your doctor on the correct dosage for you and list all other medications you are currently taking, in case any intereact with the Co Q10 supplements.

Are CoQ10 supplements safe?

Yes. CoQ10 supplementation has been carefully studied through the years by experts from different countries around the world. Clinical trial results were mostly successful but no definite conclusion has been released by the U.S. Food and Drug Administration as they do not strictly regulate supplements.


Coenzyme coq10 supplements companion products

Alpha lipoic acid, antioxynol, green tea extract and lycopene are some companion products to take with coq10 supplements that enhance its effectiveness in the body.

Alpha lipoic acid also known as thioctic acid, is a disulfide compound that is a cofactor in vital energy producing reactions in the body furthermore, it is a powerful antioxidant.

Antioxynol (Grape seed extract) contains gallic esters recently described as the most active substance known in the battle against free radicals. Antioxynol (Grape seed extract) is a pure extract of 95% OPCs which may be one of the most powerful antioxidants yet discovered.

Green Tea Extract is a very concentrated and decaffeinated form of Green Tea consolidating 60% polyphenols/catechins to create a unified blend that offers more of the protection and health enhancing effects of Green Tea without the fuss.

Lycopene has been identified as the key health-promoting compound found in rich, red tomatoes. Even having a diet rich in fruits and vegetables, it can be difficult to obtain daily servings for optimum health.

When taken with Coenzyme q10 (CoQ10) these dietary supplements will boost the immune system and enhance the Coenzyme q 10.

Are there any side effects?

Like any other vitamin or supplement, too little or too much is not good for your health. For CoQ10 supplementation, mild and usual side effects like nausea, vomiting, dizziness, heartburn, irritability have been noted but for a brief period of time only.

Is there a CoQ10 supplement overdose?

There are no reported overdose cases of CoQ10 supplement but patients who were taking 300 mg a day have reported symptoms of nervousness, fatigue, lack of focus, irritability, and insomnia.

Is CoQ10 supplement safe for pregnant women?

CoQ10 supplements are not recommended for patients who are pregnant or breastfeeding due to lack of evidence still.

Sources:

Includes material from:
“Co Q10 may help you lose weight by boosting energy within your body.”
By Maggie Greenwood-Robinson, Ph.D. (Let’s Live, December 2001)

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